The Center for Bioinformatics and Computational Biology supports research and research training in areas that join biology with the computer sciences, engineering, mathematics, and physics. Toward this end, the center develops and manages programs in computational biology, such as the generation of mathematical models of biological networks, the development of modeling and simulation tools, the conduct of basic theoretical studies related to network organization and dynamic processes, and the development of methods for the analysis and dissemination of computational models. The center also defines the Institute’s needs for database development and applications, and it collaborates with other NIH components and Federal agencies in developing policies in this area. Other center activities include the support of multidisciplinary collaborations and of workshops, courses, and specialized meetings.